Schizophrenia
Dopamine hypothesis, glutamate dysfunction, reduced gray matter, disrupted connectivity, enlarged ventricles.
© Blausen · CC-BY
Schizophrenia is a psychotic disorder involving hallucinations, delusions, disorganized thought, and negative symptoms. The dopamine hypothesis — mesolimbic hyperdopaminergia and mesocortical hypodopaminergia — remains influential alongside glutamate NMDA receptor hypofunction models. Progressive gray matter loss, enlarged ventricles, and disrupted white matter connectivity are hallmark findings. Early intervention programs improve long-term outcomes.
Symptoms
Neurology
Dopamine hypothesis, glutamate dysfunction, reduced gray matter, disrupted connectivity, enlarged ventricles.
Treatments
Gallery
Cortical thinning
Synaptic dysfunction
Striatal dopamine
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BrainFacts — Schizophrenia
via BrainFacts.org
Riisfeldt — Psychotic Disorders
via Riisfeldt Neurology Education
NeuroWiki — Schizophrenia
via NeuroWiki
AAN — Schizophrenia Resources
via AAN Medical Student Resources
Owen et al. — Schizophrenia review
via PubMed
Lancet Neurology — Schizophrenia treatment
via The Lancet Neurology
Sources & Attribution