intermediateanxietydisorderclinical
Obsessive-Compulsive Disorder
Hyperactivity in cortico-striato-thalamo-cortical circuits. Serotonin system involvement. Basal ganglia dysfunction.
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OCD features intrusive obsessions and compulsive rituals driven by cortico-striato-thalamo-cortical (CSTC) circuit hyperactivity. Serotonin reuptake inhibitors and exposure-response prevention are first-line treatments. Orbitofrontal cortex and anterior cingulate hyperactivity correlate with error monitoring dysfunction. Deep brain stimulation targeting CSTC nodes helps treatment-resistant cases.
Symptoms
Obsessive thoughtsCompulsive behaviorsAnxietyRitualistic behaviorIntrusive images
Neurology
Hyperactivity in cortico-striato-thalamo-cortical circuits. Serotonin system involvement. Basal ganglia dysfunction.
Treatments
SSRIsExposure and response preventionDeep brain stimulationCognitive therapy
Gallery
OCD neuroimaging
Orbitofrontal cortex
Serotonergic synapse
Videos
Related in NeuroSphere
basal gangliaserotoninanxietyhabit
Sources & Attribution