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Bipolar Disorder

Circadian rhythm disruption, dopamine dysregulation, white matter abnormalities, altered limbic-prefrontal connectivity.

Limbic-prefrontal circuits

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Bipolar disorder alternates between manic/hypomanic and depressive episodes with circadian rhythm disruption as a core feature. Dopamine dysregulation, white matter abnormalities, and altered limbic-prefrontal connectivity underlie mood instability. Lithium remains the gold-standard mood stabilizer with neuroprotective properties. The suprachiasmatic nucleus and clock gene variants link bipolar disorder to chronobiology.

Symptoms

Manic episodesDepressive episodesMood swingsSleep disruptionImpulsivityPsychosis

Neurology

Circadian rhythm disruption, dopamine dysregulation, white matter abnormalities, altered limbic-prefrontal connectivity.

Treatments

LithiumMood stabilizersAntipsychoticsPsychoeducationCBT

Gallery

Bipolar neuroimaging

Bipolar neuroimaging

Circadian circuits

Circadian circuits

Hippocampus

Videos

Circadian Rhythm & Mood

Huberman Lab

2-Minute Neuroscience: Depression

Neuroscientifically Challenged

Related in NeuroSphere

dopamineemotiondepressioncircadian rhythm

Explore Further

BrainFacts — Bipolar Disorder

via BrainFacts.org

Riisfeldt — Bipolar Disorder

via Riisfeldt Neurology Education

NeuroWiki — Bipolar_disorder

via NeuroWiki

AAN — Mood Disorder Resources

via AAN Medical Student Resources

Grande et al. — Bipolar disorder review

via PubMed

Lancet Neurology — Bipolar treatment

via The Lancet Neurology

Sources & Attribution

BrainFacts.org Riisfeldt Neurology Education PubMed