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Alzheimer's Disease

Amyloid plaques, neurofibrillary tangles, synaptic loss, hippocampal atrophy, cortical thinning.

Hippocampal atrophy in Alzheimer's

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Alzheimer's disease is the leading cause of dementia, defined by extracellular amyloid-beta plaques and intracellular neurofibrillary tau tangles. Hippocampal and entorhinal cortex atrophy precedes widespread cortical thinning. The amyloid cascade hypothesis guided drug development; anti-amyloid antibodies now show modest clinical benefit. Biomarkers in CSF and PET enable preclinical diagnosis decades before symptoms.

Symptoms

Memory lossConfusionLanguage problemsPersonality changesDisorientationBehavioral changes

Neurology

Amyloid plaques, neurofibrillary tangles, synaptic loss, hippocampal atrophy, cortical thinning.

Treatments

Cholinesterase inhibitorsAnti-amyloid antibodiesCognitive stimulationCaregiver support

Gallery

Alzheimer's brain comparison

Alzheimer's brain comparison

MRI atrophy

Memory circuits

Memory circuits

Videos

2-Minute Neuroscience: Hippocampus

Neuroscientifically Challenged

Brain Health Protocols

Huberman Lab

Related in NeuroSphere

hippocampusmemoryalzheimersneurodegeneration

Explore Further

BrainFacts — Alzheimer's

via BrainFacts.org

Riisfeldt — Dementia

via Riisfeldt Neurology Education

NeuroWiki — Alzheimer_disease

via NeuroWiki

AAN — Dementia Resources

via AAN Medical Student Resources

Alzheimer — Über eigenartige Erkrankungen

via PubMed

Lancet Neurology — Alzheimer's research

via The Lancet Neurology

Sources & Attribution

BrainFacts.org Riisfeldt Neurology Education PubMed